Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Identifieur interne : 000329 ( PubMed/Curation ); précédent : 000328; suivant : 000330Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Auteurs : Sonia Lavisse [France] ; Daniel García-Lorenzo [France] ; Marie-Anne Peyronneau [France] ; Benedetta Bodini [Royaume-Uni] ; Claire Thiriez [France] ; Bertrand Kuhnast [France] ; Claude Comtat [France] ; Philippe Remy ; Bruno Stankoff [France] ; Michel Bottlaender [France]Source :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 1535-5667 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Brain (diagnostic imaging), Cerebellum (diagnostic imaging), Female, Fluorine Radioisotopes (chemistry), Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Inflammation (pathology), Ligands, Male, Middle Aged, Neurodegenerative Diseases (diagnostic imaging), Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding, Pyrazoles (chemistry), Pyrimidines (chemistry), Receptors, GABA (metabolism), Thalamus (diagnostic imaging).
- MESH :
- chemical , chemistry : Fluorine Radioisotopes, Pyrazoles, Pyrimidines.
- diagnostic imaging : Brain, Cerebellum, Neurodegenerative Diseases, Thalamus.
- chemical , metabolism : Receptors, GABA.
- pathology : Inflammation.
- Adult, Female, Genotype, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Ligands, Male, Middle Aged, Polymorphism, Genetic, Positron-Emission Tomography, Protein Binding.
Abstract
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.
DOI: 10.2967/jnumed.115.156083
PubMed: 26025960
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Philippe Remy<affiliation><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.</title><author><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France sonia.lavisse@cea.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Lorenzo, Daniel" sort="Garcia Lorenzo, Daniel" uniqKey="Garcia Lorenzo D" first="Daniel" last="García-Lorenzo">Daniel García-Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Peyronneau, Marie Anne" sort="Peyronneau, Marie Anne" uniqKey="Peyronneau M" first="Marie-Anne" last="Peyronneau">Marie-Anne Peyronneau</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Bodini, Benedetta" sort="Bodini, Benedetta" uniqKey="Bodini B" first="Benedetta" last="Bodini">Benedetta Bodini</name><affiliation wicri:level="2"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Kuhnast, Bertrand" sort="Kuhnast, Bertrand" uniqKey="Kuhnast B" first="Bertrand" last="Kuhnast">Bertrand Kuhnast</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Comtat, Claude" sort="Comtat, Claude" uniqKey="Comtat C" first="Claude" last="Comtat">Claude Comtat</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Stankoff, Bruno" sort="Stankoff, Bruno" uniqKey="Stankoff B" first="Bruno" last="Stankoff">Bruno Stankoff</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26025960</idno><idno type="pmid">26025960</idno><idno type="doi">10.2967/jnumed.115.156083</idno><idno type="wicri:Area/PubMed/Corpus">000331</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000331</idno><idno type="wicri:Area/PubMed/Curation">000329</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000329</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.</title><author><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France sonia.lavisse@cea.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Lorenzo, Daniel" sort="Garcia Lorenzo, Daniel" uniqKey="Garcia Lorenzo D" first="Daniel" last="García-Lorenzo">Daniel García-Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Peyronneau, Marie Anne" sort="Peyronneau, Marie Anne" uniqKey="Peyronneau M" first="Marie-Anne" last="Peyronneau">Marie-Anne Peyronneau</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Bodini, Benedetta" sort="Bodini, Benedetta" uniqKey="Bodini B" first="Benedetta" last="Bodini">Benedetta Bodini</name><affiliation wicri:level="2"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London</wicri:cityArea></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Kuhnast, Bertrand" sort="Kuhnast, Bertrand" uniqKey="Kuhnast B" first="Bertrand" last="Kuhnast">Bertrand Kuhnast</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Comtat, Claude" sort="Comtat, Claude" uniqKey="Comtat C" first="Claude" last="Comtat">Claude Comtat</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation><nlm:affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Stankoff, Bruno" sort="Stankoff, Bruno" uniqKey="Stankoff B" first="Bruno" last="Stankoff">Bruno Stankoff</name><affiliation wicri:level="1"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bottlaender, Michel" sort="Bottlaender, Michel" uniqKey="Bottlaender M" first="Michel" last="Bottlaender">Michel Bottlaender</name><affiliation wicri:level="1"><nlm:affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="eISSN">1535-5667</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain (diagnostic imaging)</term><term>Cerebellum (diagnostic imaging)</term><term>Female</term><term>Fluorine Radioisotopes (chemistry)</term><term>Genotype</term><term>Healthy Volunteers</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Inflammation (pathology)</term><term>Ligands</term><term>Male</term><term>Middle Aged</term><term>Neurodegenerative Diseases (diagnostic imaging)</term><term>Polymorphism, Genetic</term><term>Positron-Emission Tomography</term><term>Protein Binding</term><term>Pyrazoles (chemistry)</term><term>Pyrimidines (chemistry)</term><term>Receptors, GABA (metabolism)</term><term>Thalamus (diagnostic imaging)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Pyrazoles</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Cerebellum</term><term>Neurodegenerative Diseases</term><term>Thalamus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, GABA</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Genotype</term><term>Healthy Volunteers</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Ligands</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Positron-Emission Tomography</term><term>Protein Binding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26025960</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>03</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1535-5667</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.</ArticleTitle><Pagination><MedlinePgn>1048-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2967/jnumed.115.156083</ELocationID><Abstract><AbstractText Label="UNLABELLED">Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO may be a suitable in vivo indicator of neurodegeneration. Here, we quantified the (18)F-DPA-714 radioligand in healthy TSPO-genotyped volunteers and developed a method to eliminate the need for invasive arterial blood sampling.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Ten controls (7 high-affinity binders [HABs] and 3 mixed-affinity binders [MABs]) underwent (18)F-DPA-714 PET with arterial and venous sampling. (18)F-DPA-714 binding was quantified with a metabolite-corrected arterial plasma input function, using the 1- and 2-tissue-compartment models (TCMs) as well as the Logan analysis to estimate total volume distribution (V(T)) in the regions of interest. Alternative quantification methods were tested, including tissue-to-plasma ratio or population-based input function approaches normalized by late time points of arterial or venous samples.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The distribution pattern of (18)F-DPA-714 was consistent with the known distribution of TSPO in humans, with the thalamus displaying the highest binding and the cerebellum the lowest. The 2-TCM best described the regional kinetics of (18)F-DPA-714 in the brain, with good identifiability (percentage coefficient of variation < 5%). For each region of interest, V(T) was 47.6% ± 6.3% higher in HABs than in MABs, and estimates from the 2-TCM and the Logan analyses were highly correlated. Equilibrium was reached at 60 min after injection. V(T) calculated with alternative methods using arterial samples was strongly and significantly correlated with that calculated by the 2-TCM. Replacement of arterial with venous sampling in these methods led to a significant but lower correlation.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Genotyping of subjects is a prerequisite for a reliable quantification of (18)F-DPA-714 PET images. The 2-TCM and the Logan analyses are accurate methods to estimate (18)F-DPA-714 V(T) in the human brain of both HAB and MAB individuals. Population-based input function and tissue-to-plasma ratio with a single arterial sample are promising alternatives to classic arterial plasma input function. Substitution with venous samples is promising but still requires methodologic improvements.</AbstractText><CopyrightInformation>© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lavisse</LastName><ForeName>Sonia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France sonia.lavisse@cea.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Lorenzo</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peyronneau</LastName><ForeName>Marie-Anne</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodini</LastName><ForeName>Benedetta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France Department of Neuroimaging, Institute of Psychiatry, King's College London, London, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiriez</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuhnast</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comtat</LastName><ForeName>Claude</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, MIRCen, Fontenay-aux-Roses, France CNRS-UMR9199, Universités Paris-Sud and Paris-Saclay, Fontenay-aux-Roses, France Neurology Department, Centre Expert Parkinson, CHU Henri Mondor, AP-HP, Créteil, France Paris-Est University, Créteil, France; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stankoff</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de la Moelle épinière, Inserm-U1127 and Sorbonne University, UPMC-UMRS-1127, Paris, France CNRS-UMR7225, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bottlaender</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CEA-DSV-I2BM, SHFJ and IMIV, UMR1023 Inserm/CEA/Paris-Sud University, Orsay, France CEA-DSV-I2BM, Neurospin, Gif-sur-Yvette, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005462">Fluorine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008024">Ligands</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C530129">N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011720">Pyrazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011743">Pyrimidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018079">Receptors, GABA</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C499229">TSPO protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002531" MajorTopicYN="N">Cerebellum</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005462" MajorTopicYN="N">Fluorine Radioisotopes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064368" MajorTopicYN="N">Healthy Volunteers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008024" MajorTopicYN="N">Ligands</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011720" MajorTopicYN="N">Pyrazoles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011743" MajorTopicYN="N">Pyrimidines</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018079" MajorTopicYN="N">Receptors, GABA</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">18F-DPA-714</Keyword><Keyword MajorTopicYN="N">PET</Keyword><Keyword MajorTopicYN="N">TSPO</Keyword><Keyword MajorTopicYN="N">genotyped human</Keyword><Keyword MajorTopicYN="N">quantification</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26025960</ArticleId><ArticleId IdType="pii">jnumed.115.156083</ArticleId><ArticleId IdType="doi">10.2967/jnumed.115.156083</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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